While side effects vary from patient to patient, severe side effects are incredibly rare. Your fertility specialist or your fertility pharmacy pharmacists will tell you everything you need to know about Clomid.
Most importantly, you should be prepared for what you may feel or experience as a Clomid side effect. These side effects are the result of how Clomid functions.
The medication works to stimulate reproductive hormones that cause the maturity and release of your eggs. Wherever there are hormone fluctuations, there are side effects. Almost all symptoms associated with premenstrual syndrome PMS can rear up when taking clomid. These include:. The drug is designed to stimulate your ovaries and help them produce and release more than one egg - but not as many as injectable medications. Thus, your ovaries and reproductive tract can become inflamed, leading to tenderness, bloating and even stomach upset.
While some women only experience the mild stomach upset, we mentioned above, others have full-blown nausea, vomiting, and diarrhea. Read up on natural remedies for supporting an irritated stomach , so you have the right ingredients on hand at home if this happens to you.
If this is the case for you, wearing an ultra-supportive bra, such as a sports bra, can help. Minimizing higher-impact activities also limits discomfort. As we mentioned in our post, Fertility Medications: Expectations vs. Select basic ads. Create a personalised ads profile.
Select personalised ads. Apply market research to generate audience insights. Measure content performance. Develop and improve products. List of Partners vendors. Clomid clomiphene side effects are mild for most people. The most common ones include hot flashes, headaches, bloating, mood swings, and breast tenderness. However, as with any drug, you should be aware of the potential risks before treatment. Clomid may also be sold under its generic name clomiphene or under the brand name Serophene.
These medications are all the same drug. Many Clomid side effects are the result of how the drug works. It does this by blocking estrogen receptors. These hormones stimulate the ovaries and boost ovulation.
Most of the other side effects are caused by the ovaries becoming slightly enlarged. Not all possible side effects and risks are listed below. If you are experiencing severe side effects, unusual symptoms, or are concerned for any reason, contact your doctor.
Consult with your doctor to get a personalized assessment of your risks for various side effects and to address any questions or concerns you may have. Hot flashes or, in official doctor-speak, "vasomotor flushes" are a common side effect of clomiphene. About 1 in 10 women experienced them in clinical studies.
After a hot flash, you might feel chilled, especially if you broke out in a sweat. A hot flash can be a bit unnerving the first time it happens. Another very common clomiphene side effect is bloating and abdominal discomfort. The bloated feelings should pass once your treatment cycle is over.
Of course, if you experience more than moderate discomfort and cramps, call your doctor. Severe bloating or abdominal tenderness may be a sign of ovarian hyperstimulation syndrome. What might explain why so few reported weight gain in early research, but so many people online complain about adding on pounds when taking Clomid? One possible explanation is the weight gain is a temporary outcome of bloating.
Bloating is common during Clomid treatment, as is retaining water weight. If the weight gain is connected to bloating, then your weight should go back to normal after treatment. Another possibility is the stress of treatment leads to unhealthy eating.
The best way to combat this is to plan your meals and have healthy, fertility-friendly snacks around when you get the munchies. However, later studies found that almost half of all people taking Clomid experience mood disturbances. Mood swings may mean feeling more emotionally sensitive, tearful, or even depressed or anxious. Infertility itself can bring on these feelings without drugs. Try to be forgiving and gentle with yourself and practice good self-care during treatment.
Taking the medication in the evening may help. If the nausea is intense, or you have trouble keeping down food and fluids, be sure to report this to your doctor. Severe nausea can also be a sign of ovarian hyperstimulation syndrome, a rare but potentially dangerous side effect of fertility drugs. This is another side effect that might lead you to wonder if you're experiencing early pregnancy symptoms. Some people may see spotting and think that it is implantation spotting. You shouldn't necessarily assume it's a pregnancy sign.
Contact your doctor if the spotting is accompanied by other symptoms, such as:. This way, you can sleep through the pain.
If your doctor told you to specifically take the medication in the morning, ask first. Also be sure to get plenty of fluids, since mild dehydration can cause headaches. The U. Food and Drug Administration FDA approved this oral fertility medication for use in women who are unable to become pregnant.
It affects the hormone balance within the body and promotes ovulation. The FDA approved Clomid only for use in women.
Learn more about off-label prescription drug use. Clomid blocks the hormone estrogen from interacting with the pituitary gland. When estrogen interacts with the pituitary gland, less luteinizing hormone LH and follicle-stimulating hormone FSH are produced.
This leads to a decrease in testosterone and therefore decreased sperm production. The dose given can range from A recent review recommends a starting dosage of 25 mg three days per week and then slowly titrating — or adjusting the dosage — until the dose is 50 mg per day as needed. High doses of Clomid can actually have a negative effect on sperm count and motility. Always work with your healthcare provider to ensure proper dosage.
Clomid is prescribed off-label for male infertility, particularly where low testosterone levels are observed. According to the Centers for Disease Control and Prevention , both a male and a female factor are identified in 35 percent of couples who encounter challenges trying to conceive. In 8 percent of couples, only a male factor is identified.
There are few controlled studies of Clomid use in males. However, possible side effects due to induced hormonal changes include:. The side effects of Clomid are typically reversible after stopping the medication. If any of the side effects listed above occur while taking Clomid, discontinue taking Clomid and seek medical treatment.
A recent review of Clomid use in male infertility cases found mixed results regarding efficacy, or effectiveness. Some of the studies reviewed demonstrated a moderate improvement in sperm count in males with low sperm count or unexplained infertility.
Others indicated no improvement when compared to either placebo or an untreated control. This was especially true when looking at pregnancy outcomes. A recent study showed an increase in pregnancies when infertile males took a combination of Clomid and vitamin E when compared to placebo.
As a result, the study was unable to provide information regarding whether combining Clomid with vitamin E increases efficacy as it relates to pregnancy. In a study , researchers divided participants diagnosed with male infertility into three groups:. The study results showed an increase in the average sperm concentration across all three groups. Group C showed the highest increase.
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